Tessera therapeutics5/18/2023 ![]() ![]() However, as mentioned, CRISPR is ok for deleting part of a gene with a (statistically) quite good accuracy but it is not that good when the goal is to create new sequences of DNA, new genes. We can expect a growing usage of CRISPR in clinical medicine in the coming years. The technology used is thee one provided by Crispr Therapeutics. In 2020 we had the first use of CRISPR on a person affected by sickle cell anemia, a genetic malfunction, and after a year she is doing extremely well. Again, if statistically the outcome is by far better than the option of don’t doing anything (very low risk of side effects) it makes sense to do that. On the other hand there is always the -remote- possibility that some of the changes may go awry and this might create problem. If, statistically speaking, the majority of them aree affected in the way you are expecting you should get a good result. Think about it: by using CRISPR/Cas9 on a single cell in the lab (in a Petri dish) you can see what is happening, but if you are “injecting” in a body the CRISPR/Cas 9 this is going to affect hundreds of thousands, millions of cells and you can’t be sure what is going on in each single one (most likely something slightly different in different cells). Sometimes this is ok, sometimes it is not and most of the times we are not sure what is the case. You are dealing with millions / billions of molecules and you are playing some sort of statistical game. The problem, in biology, is that you are not working with a few cogs and wheels that you can identify, select and manipulate. Of course one thing is to be able to do this, quite a different story is to reach a point where you are sure you are actually doing what you want to do. With CRISPR/Cas9 it has become possible to cut undesired parts of a gene and splice other parts together. The discovery of the DNA first and the sequencing of the human genome have created huge expectation for a future where it would be possible to radically cure/stop genetic diseases (and there are over 6,000 genetic disorders already identified).Ĭlearly the first step is to understand what might be wrong in the genes but this is not going to help unless there is a way to patch up the faulty genes.Ī real turning point was the discovery of CRISPR / Cas9 and of methods and technology to use it. If you find this information useful, Please Share with your friends.įeel free to reach out for any suggestions or feedback.A rendering of replacing a DNA strand with another one to re-write a gene. Sometimes ,this information may not be accurate because datafiles constantly keep changing. Usually Total Compensation includes : Base Salary + RSU / Stocks + Bonus + Miscellaneous Benefits. Big Tech Players usually pay fair amount of compensation through stocks and bonuses which is not captured as part of H1B Salary Information. Compensation structures vary greatly across industries, and rarely is base salary the sole indicator of how much an individual will receive in total take home pay especially big technology players. This salary information is good starting point for understanding the market for a given role and geographic location, it is often misleading or incomplete because it only states base salary information for the job title. Prior to filing the H-1B petition with the USCIS, an employer must file a LCAĪ Labor Condition Application ("LCA") is used by employers as supporting evidence forĭOL disclosure data does not indicate the employer's intended use for the LCA. This website indexed About 10 Million Labor Condition ![]() Information to help potential job seekers and others. The primary purpose of this portal is democratization of publicly available salary ![]()
0 Comments
Leave a Reply. |